Ethanol → 4-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole

HRID 744719ノート

反応式

HRID 744719 の反応式
C([N:8]1[C:12]([C:13]([OH:37])([C:24]2[CH:29]=[CH:28][C:27]([C:30]([NH:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])=[CH:26][CH:25]=2)[CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)=[CH:11][N:10]=[CH:9]1)C1C=CC=CC=1.C(O)C.C([O-])=O.[NH4+]>[Pd].O>[F:23][C:20]1[CH:21]=[CH:22][C:17]([CH2:16][CH2:15][CH2:14][C:13]([C:12]2[N:8]=[CH:9][NH:10][CH:11]=2)([OH:37])[C:24]2[CH:29]=[CH:28][C:27]([C:30]([NH:32][C:33]([CH3:34])([CH3:35])[CH3:36])=[O:31])=[CH:26][CH:25]=2)=[CH:18][CH:19]=1

参加物

6

反応物 3

HCID 702EthanolHCID 2723923Ammonium formateHCID 194219951-benzyl-5-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1-H-imidazole

生成物 1

HCID 1784493104-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

実験手順

12,95 g of 1-benzyl-5-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1-H-imidazole is dissolved into ethanol (400 ml) and water (130 ml). 8,17 g of ammonium formate and 1,3 g of 10% Pd/C is added to the solution and the mixture is refluxed for three hours. Then the reaction mixture is filtered through siliceous earth and the flitrate is evaporated to dryness. The residue is dissolved into ethyl acetate, washed with 2M aqueous sodium hydroxide and water, dried and evaporated to dryness.

後処理

  1. temperaturethe mixture is refluxed for three hours
  2. filtrationThen the reaction mixture is filtered through siliceous earth
  3. customthe flitrate is evaporated to dryness
  4. dissolutionThe residue is dissolved into ethyl acetate
  5. washwashed with 2M aqueous sodium hydroxide and water
  6. customdried
  7. customevaporated to dryness

出典と根拠

ORDレコード
ord-f491f2ceab98476cbd872f0c8094d752
出典データセット
uspto-grants-1996_09
特許番号
US05559141

反応ノート

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