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Ammonium formate → 4-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole

HRID 744724
ノート
印刷プレビュー

反応式

HRID 744724 の反応式
Cl.C([N:9]1[C:13]([C:14]([OH:38])([C:25]2[CH:30]=[CH:29][C:28]([C:31]([NH:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])=[CH:27][CH:26]=2)[CH2:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)=[CH:12][N:11]=[CH:10]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd].C(O)C>[F:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][CH2:16][CH2:15][C:14]([C:13]2[N:9]=[CH:10][NH:11][CH:12]=2)([OH:38])[C:25]2[CH:30]=[CH:29][C:28]([C:31]([NH:33][C:34]([CH3:35])([CH3:36])[CH3:37])=[O:32])=[CH:27][CH:26]=2)=[CH:19][CH:20]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 194220141-benzyl-5-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole hydrochloride

生成物 1

HCID 1784493104-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole収率 79%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol
溶媒

実験手順

1-benzyl-5-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole hydrochloride (12,95 g) is dissolved into aqueous ethanol (400 ml) and 1,3 g of 10% Pd/C is added. Ammonium formate (8,17 g) is added to the boiling solution in small portions. The mixture is refluxed for three hours. Then the reaction mixture is filtered through siliceous earth and the filtrate is evaporated to dryness. The residue is dissolved to methylene chloride, washed with 2M sodiumhydroxide and water, dried and evaporated to dryness. Yield 79%.

後処理

  1. additionis added
  2. temperatureThe mixture is refluxed for three hours
  3. filtrationThen the reaction mixture is filtered through siliceous earth
  4. customthe filtrate is evaporated to dryness
  5. dissolutionThe residue is dissolved to methylene chloride
  6. washwashed with 2M sodiumhydroxide and water
  7. customdried
  8. customevaporated to dryness

出典と根拠

ORDレコード
ord-c16b678e3e844f2f9de1b75692c34f48
出典データセット
uspto-grants-1996_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05559141

反応ノート

読み込み中…

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