Benzene → 9-Methyl-9h-carbazol-2-ol

HRID 744874ノート

反応式

HRID 744874 の反応式
[OH:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[NH:5][C:4]=2[CH:3]=1.[OH-].[Na+].[CH:17]1C=CC=CC=1.CI>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.O>[OH:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]([CH3:17])[C:4]=2[CH:3]=1

参加物

7

反応物 4

HCID 241BenzeneHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 935512-Hydroxycarbazole

生成物 1

HCID 1878409-Methyl-9h-carbazol-2-ol

試薬・触媒・溶媒 2

HCID 66133Benzyl triethylammonium chloride触媒HCID 962Water溶媒

実験手順

To a mixture comprising 20 g of 2-hydroxycarbazole, 3 g of benzyltriethyl ammonium chloride, 70 ml of a 50% aqueous solution of sodium hydroxide and 10 ml of benzene was added dropwise 25 g of methyl iodide. After the dropwise addition, the mixture was stirred for 2 hours. The mixture was poured into hot water and the mixture was allowed to stand at room temperature overnight. The precipitated solid was recovered by filtration, washed with water and dried to obtain a yellowish brown solid of 2-hydroxy-9-methylcarbazole.

後処理

  1. additionAfter the dropwise addition
  2. waitto stand at room temperature overnight
  3. filtrationThe precipitated solid was recovered by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-975037668a094fdd82e19f58a1c40dbe
出典データセット
uspto-grants-1996_09
特許番号
US05559231

反応ノート

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