Diisopropylethylamine → (6-Chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone

HRID 74510

反応式

HRID 74510 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8](Cl)=[O:9])[CH:3]=1.CCN(C(C)C)C(C)C.[NH:20]1[CH:28]2[CH:23]([CH2:24][CH2:25][CH2:26][CH2:27]2)[CH2:22][CH2:21]1>ClCCl>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([N:20]2[CH:28]3[CH:23]([CH2:24][CH2:25][CH2:26][CH2:27]3)[CH2:22][CH2:21]2)=[O:9])[CH:3]=1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 107275Octahydro-1H-indoleHCID 184220986-Chloropyrimidine-4-carbonyl chloride

生成物 1

HCID 58386728(6-Chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

実験手順

0.517 g (2.92 mmol) 6-chloropyrimidine-4-carboxylic acid chloride in 10 mL dichloromethane were combined with 1.07 mL (6.00 mmol) DIPEA. 0.73 g (2.92 mmol) octahydroindole in 10 mL DCM was slowly added dropwise. After 2 h stirring at RT the mixture was diluted with dichloromethane and extracted with water. The organic phase was separated off, dried on sodium sulphate, filtered, evaporated down i. vac. and dried.

後処理

  1. extractionextracted with water
  2. customThe organic phase was separated off
  3. customdried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down i
  6. customand dried

出典と根拠

ORDレコード
ord-d9e6d1a79cb5434b9b413788f1e27a35
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

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