1H-Indole-3-propanoic acid → 3-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one

HRID 74521

反応式

HRID 74521 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][C:12]([OH:14])=O)=[CH:2]1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(CC)CC)C>CN(C=O)C>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][C:12]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[O:14])=[CH:2]1

参加物

6

反応物 4

HCID 37441H-Indole-3-propanoic acidHCID 8471TriethylamineHCID 31268PyrrolidineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

生成物 1

HCID 48067833-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

681 mg (3.60 mmol) 3-(1H-indol-3-yl)-propionic acid, 0.3 mL (3.60 mmol) pyrrolidine, 1.13 g (3.50 mmol) TBTU and 0.98 mL (7.00 mmol) triethylamine in 5.0 mL DMF were stirred overnight at RT. The mixture was purified by preparative HPLC. The product fractions were combined and evaporated down i. vac.

後処理

  1. customThe mixture was purified by preparative HPLC
  2. customevaporated down i

出典と根拠

ORDレコード
ord-1df2c89023ab44e3bf397e899e470f39
出典データセット
uspto-grants-2014_09
特許番号
US08829006B2

関連ノート

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