Sodium Hydroxide → HCID 13251820、化合物

HRID 745484

反応式

HRID 745484 の反応式
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH2:8].[C:9]([C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([CH3:23])[CH2:21]Cl)=[CH:15][CH:14]=1)([CH3:12])([CH3:11])[CH3:10].[OH-].[Na+]>CCOCC>[C:9]([C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH:20]([CH3:23])[CH2:21][NH:1][C@@H:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]2[NH2:8])=[CH:17][CH:18]=1)([CH3:12])([CH3:11])[CH3:10]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 438061,2-Diaminocyclohexane, trans-HCID 132518171-tert-Butyl-4-(3-chloro-2-methylpropyl)benzene

生成物 1

HCID 13251820HCID 13251820、化合物収率 83.5%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
140 °C

実験手順

274 g of trans-1,2-diaminocyclohexane and 134.4 g of 3-(4-tert.-butylphenyl)-2-methylpropyl chloride (German Laid-Open Application DOS No. 2,752,096) were stirred for 10 hours at 140° C. and then cooled to +10° C. in an ice bath, and 200 ml of a 50% strength by weight sodium hydroxide solution were added slowly, followed by the addition of 200 ml of ether. The organic phase was separated off, dried over potassium hydroxide and distilled to give 151 g of N-(3-(4-tert.-butylphenyl)-2-methylpropyl)-trans-1,2-diaminocyclohexane of boiling point 175°-180° C./0.3 mbar. Yield: 83.3% of theory.

後処理

  1. temperaturecooled to +10° C. in an ice bath
  2. customThe organic phase was separated off
  3. dry with materialdried over potassium hydroxide
  4. distillationdistilled

出典と根拠

ORDレコード
ord-9d6febe3472e4acb8c5384b0ade92637
出典データセット
uspto-grants-1986_07
特許番号
US04599335

関連ノート

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