Ethanolamine → 3-(2-Aminoethoxy)-6-chloropyridazine hydrochloride

HRID 745502ノート

反応式

HRID 745502 の反応式
[H-].[Na+].[NH2:3][CH2:4][CH2:5][OH:6].[Cl:7][C:8]1[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=1>C1C=CC=CC=1>[ClH:7].[NH2:3][CH2:4][CH2:5][O:6][C:11]1[N:10]=[N:9][C:8]([Cl:7])=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 700EthanolamineHCID 24758Sodium hydrideHCID 673313,6-Dichloropyridazine

生成物 1

HCID 233135663-(2-Aminoethoxy)-6-chloropyridazine hydrochloride収率 54.2%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a suspension of 4.2 g of 61% sodium hydride in 100 ml of benzene was added dropwise 6.2 g of 2-aminoethanol at room temperature. Then, 15 g of 3,6-dichloropyridazine was added, and the mixture was refluxed for 1 hour. After cooling, the reaction mixture was washed with water, and dried over magnesium sulfate. After evaporating the solvent, the residue was treated with hydrogen chrolide-ether solution to give 5.73 g of 3-(2-aminoethoxy)-6-chloropyridazine hydrochloride as crystals.

後処理

  1. temperaturethe mixture was refluxed for 1 hour
  2. temperatureAfter cooling
  3. washthe reaction mixture was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customAfter evaporating the solvent
  6. additionthe residue was treated with hydrogen chrolide-ether solution

出典と根拠

ORDレコード
ord-5c6ef1edb3be4f9d8326bfb04e2e20ab
出典データセット
uspto-grants-1986_07
特許番号
US04599333

反応ノート

読み込み中…