2-Methoxy-2-amino-1-propanol → tert-butyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate

HRID 746194

反応式

HRID 746194 の反応式
CO[C:3]([NH2:7])([CH3:6])[CH2:4][OH:5].[C:8](=[O:15])([O-])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11].[C:16](=O)([O-])OC(C)(C)C>C([O-])(O)=O.[Na+].C(O)(C)(C)C>[C:8]([NH:7][C:3]([CH3:6])([CH3:16])[CH2:4][OH:5])([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:15]

参加物

5

反応物 2

HCID 202408182-Methoxy-2-amino-1-propanolHCID 52911111Di-tert-butyl di-carbonate

生成物 1

HCID 14578673tert-butyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate

試薬・触媒・溶媒 2

HCID 6386tert-Butanol溶媒HCID 516892Sodium Bicarbonate溶媒

実験手順

2-Methoxy-2-amino-1-propanol is dissolved in saturated aqueous NaHCO3 at room temperature. Di-tert-butyl di-carbonate is added in tert-butanol. The contents are stirred overnight and then extracted with ethyl acetate. The organic layer is dried over MgSO4 and filtered. The filtrate is evaporated to give N-Boc-2-amino-2-methyl-1-propanol.

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer is dried over MgSO4
  3. filtrationfiltered
  4. customThe filtrate is evaporated

出典と根拠

ORDレコード
ord-1873053f5d6c4ed1bb1425d87b1ec683
出典データセット
uspto-grants-1986_07
特許番号
US04603011

関連ノート

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