Oxalyl chloride → 4-[(2-pyrrolidinyl-1H-benzimidazol-1yl)methyl]benzoyl chloride
反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[N:7]1([C:12]2[N:16]([CH2:17][C:18]3[CH:26]=[CH:25]C(C(O)=O)=[CH:20][CH:19]=3)[C:15]3[CH:27]=[CH:28][CH:29]=[CH:30][C:14]=3[N:13]=2)[CH2:11][CH2:10][CH2:9][CH2:8]1>C(Cl)(Cl)Cl>[N:7]1([C:12]2[N:16]([CH2:17][C:18]3[CH:19]=[CH:20][C:1]([C:2]([Cl:4])=[O:3])=[CH:25][CH:26]=3)[C:15]3[CH:27]=[CH:28][CH:29]=[CH:30][C:14]=3[N:13]=2)[CH2:11][CH2:10][CH2:9][CH2:8]1参加物
4
実験手順
Oxalyl chloride (4 mL) was added to a suspension of 4-[(2-pyrrolidinyl-1H-benzimidazol-1yl)methyl]benzoic acid (0.28 g, 0.872 mmol) in chloroform (50 mL). The mixture was heated at reflux for 1 hour and then concentrated under vacuum. The residue was diluted with toluene, concentrated under vacuum and then dried under vacuum at ambient temperature over the weekend to provide crude 4-[(2-pyrrolidinyl-1H-benzimidazol-1yl)methyl]benzoyl chloride.