Dimethylformamide → 6-Morpholinonicotinoyl Chloride

HRID 746512

反応式

HRID 746512 の反応式
CN(C)C=O.[C:6](Cl)(=O)[C:7]([Cl:9])=[O:8].[O:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:26]=[CH:25]C(C(O)=O)=[CH:20][N:19]=2)[CH2:14][CH2:13]1>C(Cl)(Cl)Cl>[O:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:26]=[CH:25][C:6]([C:7]([Cl:9])=[O:8])=[CH:20][N:19]=2)[CH2:14][CH2:13]1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27764606-Morpholinonicotinic Acid

生成物 1

HCID 27764616-Morpholinonicotinoyl Chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

N,N-Dimethylformamide (1 mL) was slowly added to a solution of oxalyl chloride (0.13 g, 1 mmol) in chloroform (5 mL). 6-Morpholinonicotinic acid (0.21 g, 1 mmol) was added and the reaction mixture was stirred for 15 minutes. The reaction mixture was concentrated under vacuum, diluted with toluene and then concentrated under vacuum to provide 6-morpholinonicotinoyl chloride. This material was kept under vacuum at ambient temperature overnight and then used in the next step.

後処理

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. additiondiluted with toluene
  3. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-54d88a15fe754b5889ed92f48cc82849
出典データセット
uspto-grants-2008_07
特許番号
US07393859B2

関連ノート

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