Hydrochloric Acid → HCID 69212897、化合物

HRID 746655ノート

反応式

HRID 746655 の反応式
[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[C:9]([C:13]([O:15]C)=[O:14])=[C:10]([CH3:12])[S:11][C:5]=2[N:4]([CH:17]([CH3:19])[CH3:18])[C:3]1=[O:20].CO.[OH-].[Na+].Cl>C1COCC1>[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[C:9]([C:13]([OH:15])=[O:14])=[C:10]([CH3:12])[S:11][C:5]=2[N:4]([CH:17]([CH3:18])[CH3:19])[C:3]1=[O:20]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 17974723Methyl 1-isopropyl-3,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno(2,3-d)pyrimidine-5-carboxylate

生成物 1

HCID 69212897HCID 69212897、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of the product of step b) (3.81 g) in THF (50 ml) and methanol (5 ml) was added 1N NaOH (25.7 ml) and the mixture stirred under nitrogen for 18 hr. It was acidified with 2.5N HCl and extracted with DCM, the organic extracts washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure to give the sub-title compound as a solid (3.40 g)

後処理

  1. extractionextracted with DCM
  2. washthe organic extracts washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-c2b9f90ec9374a2dacf5dea18b7b4e5a
出典データセット
uspto-grants-2008_07
特許番号
US07393854B2

反応ノート

読み込み中…