Allyl Alcohol → [3-(5-Bromopyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methanol
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]=[N:9][OH:10])=[N:6][CH:7]=1.[CH2:11]([OH:14])[CH:12]=[CH2:13]>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH2:13][CH:12]([CH2:11][OH:14])[O:10][N:9]=2)=[N:6][CH:7]=1参加物
4
実験手順
5-Bromo-pyridine-2-carbaldehyde oxime (60 g, 298.5 mmol) and allyl alcohol (49.7 ml) were added to tetrahydrofuran (200 ml) and then bleach (2016 ml) was added. The reaction was stirred for four hours followed by extraction with tetrahydrofuran (2×200 ml). The organic layers were combined, dried over sodium sulfate, and concentrated in vacuo to give the desired product (38.8 g).
後処理
- additionwas added
- extractionfollowed by extraction with tetrahydrofuran (2×200 ml)
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-5f60ec7388bc4a3c8b627aada4cdbde8
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07396847B2
反応ノート
読み込み中…