Benzocaine → Ethyl 4-(pyrrolidin-1-yl)benzoate

HRID 747674

反応式

HRID 747674 の反応式
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.Br[CH2:14][CH2:15][CH2:16][CH2:17]Br.C(N(C(C)C)CC)(C)C>C1C=CC=CC=1.O>[N:1]1([C:2]2[CH:3]=[CH:4][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:11][CH:12]=2)[CH2:17][CH2:16][CH2:15][CH2:14]1

参加物

6

反応物 3

HCID 2337BenzocaineHCID 80561,4-DibromobutaneHCID 81531Diisopropylethylamine

生成物 1

HCID 773371Ethyl 4-(pyrrolidin-1-yl)benzoate

試薬・触媒・溶媒 2

HCID 241Benzene溶媒HCID 962Water溶媒

実験手順

1.69 g (10.2 mmol) of ethyl 4-aminobenzoate was dissolved in 10 ml of benzene. 2.18 g (10.1 mmol) of 1,4-dibromobutane and 3.53 ml (20.2 mmol) of diisopropylethylamine were added to the solution, and they were heated under reflux for 48 hours. The reaction solution was diluted with water. After the extraction with ethyl acetate, the organic layer was washed with water and then with saturated Aqueous NaCl solution and dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the crude title compound.

後処理

  1. temperaturewere heated
  2. temperatureunder reflux for 48 hours
  3. extractionAfter the extraction with ethyl acetate
  4. washthe organic layer was washed with water
  5. dry with materialwith saturated Aqueous NaCl solution and dried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-8ee89e0e9cdc44f5953a58535c2cc55c
出典データセット
uspto-grants-2008_07
特許番号
US07396844B1

関連ノート

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