Sodium Hydroxide → 5-Amino-4-fluoro-2-methylphenol
反応式
[F:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([OH:11])=[C:4]([CH3:12])[CH:3]=1.[OH-].[Na+]>O.[Fe].S([O-])([O-])(=O)=O.[Fe+2]>[F:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]([OH:11])=[CH:6][C:7]=1[NH2:8]参加物
6
実験手順
A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was heated at reflux for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.
後処理
- temperaturewas heated
- temperatureat reflux for 4 hours
- temperatureto cool
- extractionextracted with ethyl acetate (100 ml)
- extractionThe ethyl acetate extract
- dry with materialwas dried (MgSO4)
- customthe solvent removed by evaporation
出典と根拠
- ORDレコード
- ord-994883380a214f47b45d3a084572d5ee
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087602B2
反応ノート
読み込み中…