Sodium Hydroxide → 5-Amino-4-fluoro-2-methylphenol

HRID 7481

反応式

HRID 7481 の反応式
[F:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([OH:11])=[C:4]([CH3:12])[CH:3]=1.[OH-].[Na+]>O.[Fe].S([O-])([O-])(=O)=O.[Fe+2]>[F:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]([OH:11])=[CH:6][C:7]=1[NH2:8]

参加物

6

反応物 2

HCID 14798Sodium HydroxideHCID 108210594-Fluoro-2-methyl-5-nitrophenol

生成物 1

HCID 101540985-Amino-4-fluoro-2-methylphenol収率 47%

試薬・触媒・溶媒 3

HCID 23925Iron触媒HCID 24393Ferrous Sulfate触媒HCID 962Water溶媒

実験手順

A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was heated at reflux for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 4 hours
  3. temperatureto cool
  4. extractionextracted with ethyl acetate (100 ml)
  5. extractionThe ethyl acetate extract
  6. dry with materialwas dried (MgSO4)
  7. customthe solvent removed by evaporation

出典と根拠

ORDレコード
ord-994883380a214f47b45d3a084572d5ee
出典データセット
uspto-grants-2006_08
特許番号
US07087602B2

関連ノート

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