Benzyl Alcohol → 4-Benzyloxy-3-chloronitrobenzene

HRID 748618

反応式

HRID 748618 の反応式
[OH-].[K+].[Cl:3][C:4]1[CH:5]=[C:6]([N+:11]([O-:13])=[O:12])[CH:7]=[CH:8][C:9]=1F.[CH2:14]([OH:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(#N)C>[CH2:14]([O:21][C:9]1[CH:8]=[CH:7][C:6]([N+:11]([O-:13])=[O:12])=[CH:5][C:4]=1[Cl:3])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 14797Potassium HydroxideHCID 676882-Chloro-1-fluoro-4-nitrobenzene

生成物 1

HCID 3085094-Benzyloxy-3-chloronitrobenzene収率 75.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A 15.43 g (0.275 moles) portion of solid (pellets) potassium hydroxide was added to a solution of 43.89 g (0.25 moles) of 3-chloro-4-fluoro nitrobenzene and 32.34 ml (33.79 grams, 0.373 moles) of benzyl alcohol in 220 ml of acetonitrile. The reaction was vigorously stirred with a mechanical stirrer overnight. The resulting solid was filtered. Concentration of the filtrate gave a second crop, which was also filtered. On standing more solid came out of this filtrate. This mixture was treated with ether, and the solid filtered. All solids were washed thoroughly with water, and combined to give 49.71 g of the title compound.

後処理

  1. filtrationThe resulting solid was filtered
  2. customConcentration of the filtrate gave a second crop, which
  3. filtrationwas also filtered
  4. additionThis mixture was treated with ether
  5. filtrationthe solid filtered
  6. washAll solids were washed thoroughly with water

出典と根拠

ORDレコード
ord-01180654a1d3484bb1da5562a6ea6559
出典データセット
uspto-grants-2008_07
特許番号
US07399865B2

関連ノート

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