Thionyl Chloride → 4-Benzyloxy-1-methyl-1H-indole-2-carbonyl chloride

HRID 749296

反応式

HRID 749296 の反応式
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([OH:21])=O)[N:13]2[CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:24])=O>C1C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([Cl:24])=[O:21])[N:13]2[CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 47776784-Benzyloxy-1-methyl-1H-indole-2-carboxylic acid

生成物 1

HCID 220548724-Benzyloxy-1-methyl-1H-indole-2-carbonyl chloride

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

反応条件

温度
80 °C

実験手順

To a stirred suspension of 4-benzyloxy-1-methyl-1H-indole-2-carboxylic acid (0.75 g) in benzene (5 mL) was added thionyl chloride (2.8 mL) in benzene (5 mL) followed by heated at 80° C. for 45 min. to give a clear orange solution. Evaporation to dryness gave 0.80 g of the title compound as an orange solid, which was used without further purification.

後処理

  1. customto give a clear orange solution
  2. customEvaporation to dryness

出典と根拠

ORDレコード
ord-9b7c208217634ef2acf1a25b4db3a35f
出典データセット
uspto-grants-2008_07
特許番号
US07402604B2

関連ノート

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