Sodium hydride → 2-(3,3,4,4,4-Pentafluorobutyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile

HRID 749524

反応式

HRID 749524 の反応式
[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:15]=[CH:14][C:7]([CH2:8][CH:9]([C:12]#[N:13])[C:10]#[N:11])=[CH:6][CH:5]=1.[H-].[Na+].I[CH2:21][CH2:22][C:23]([F:29])([F:28])[C:24]([F:27])([F:26])[F:25]>CN(C)C=O>[F:28][C:23]([F:29])([C:24]([F:27])([F:26])[F:25])[CH2:22][CH2:21][C:9]([CH2:8][C:7]1[CH:6]=[CH:5][C:4]([O:3][C:2]([F:16])([F:17])[F:1])=[CH:15][CH:14]=1)([C:12]#[N:13])[C:10]#[N:11]

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 1100921,1,1,2,2-Pentafluoro-4-iodobutaneHCID 22235052(4-(Trifluoromethoxy)benzyl)malononitrile

生成物 1

HCID 222350052-(3,3,4,4,4-Pentafluorobutyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile収率 31.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Using 0.30 g of (4-(trifluoromethoxy)benzyl)malononitrile, 10 ml of N,N-dimethylformamide, 0.06 g of sodium hydride (60% in oil), and 0.38 g of 4-iodo-1,1,1,2,2-pentafluorobutane, and according to the process described in the Production Example 1, there was obtained 0.15 g of 2-(3,3,4,4,4-pentafluorobutyl)-2-(4-(trifluoromethoxy)benzyl)malononitrile (the present compound (10)).

出典と根拠

ORDレコード
ord-95c75244584e4461904f1563ff76d33a
出典データセット
uspto-grants-2008_07
特許番号
US07402691B2

関連ノート

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