Isopropanol → 4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride

HRID 7503

反応式

HRID 7503 の反応式
Cl.[Cl:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]=[N:5][CH:4]=1.[Cl:25][C:26]1[CH:32]=[CH:31][C:29]([NH2:30])=[C:28]([F:33])[CH:27]=1.C(O)(C)C>CC(O)CCC.Cl>[ClH:2].[Cl:25][C:26]1[CH:32]=[CH:31][C:29]([NH:30][C:3]2[C:12]3[C:7](=[CH:8][C:9]([O:15][CH2:16][CH2:17][CH2:18][N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[C:10]([O:13][CH3:14])[CH:11]=3)[N:6]=[N:5][CH:4]=2)=[C:28]([F:33])[CH:27]=1

参加物

6

反応物 3

HCID 3776IsopropanolHCID 938984-Chloro-2-fluoroanilineHCID 219910584-Chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride

生成物 1

HCID 219910164-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride収率 106.3%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 223862-Pentanol溶媒

反応条件

温度
120 °C

実験手順

A solution of 4-chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride (150 mg, 0.36 mmol), (prepared as described for the starting material in Example 12), 4-chloro-2-fluoroaniline (77 mg, 0.53 mmol) in 2-pentanol (4 ml) and 5M isopropanolic hydrogen chloride (1 ml) was heated at 120° C. for 1 hour. The mixture was allowed to cool and isopropanol was added. The resulting precipitate was collected by filtration, washed with ether and dried under vacuum to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride (185 mg, 98%).

後処理

  1. temperatureto cool
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with ether
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-0b7086452ac64a56a87f5db7ea740a99
出典データセット
uspto-grants-2006_08
特許番号
US07087602B2

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