Acetaldehyde → HCID 178418787、化合物

HRID 7514

反応式

HRID 7514 の反応式
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[C:16]([N+:20]#[C-:21])([CH3:19])([CH3:18])[CH3:17].[CH:22](=[O:24])[CH3:23].[C:25]([Cl:28])(=O)[CH3:26]>Cl(O)(=O)(=O)=O>[Cl-:28].[C:22]([N+:1]1[C:25]([CH3:26])=[C:21]([NH:20][C:16]([CH3:19])([CH3:18])[CH3:17])[N:3]2[CH:4]=[CH:5][CH:6]=[C:7]([O:8][CH2:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:2]=12)(=[O:24])[CH3:23]

参加物

6

反応物 4

HCID 177AcetaldehydeHCID 6367Acetyl chlorideHCID 23577Tert-Butyl isocyanideHCID 903342-Amino-3-benzyloxypyridine

生成物 1

HCID 178418787HCID 178418787、化合物

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid溶媒

実験手順

Example 8 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-3-benzyloxypyridine (0.1 M, DCM), 0.575 ml (0.115 mmol) tert.-butylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) acetaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

出典と根拠

ORDレコード
ord-3a15bd302b0f40aeacc3b2b1e11e8715
出典データセット
uspto-grants-2006_08
特許番号
US07087607B2

関連ノート

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