Pyridine → Darinaparsin

HRID 751477

反応式

HRID 751477 の反応式
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].[CH3:21][As:22]([CH3:24])Cl.N1C=CC=CC=1>COCCOC>[CH3:21][As:22]([CH3:24])[S:13][CH2:12][C@@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[NH:10][C:8](=[O:9])[CH2:7][CH2:6][C@@H:2]([C:3]([OH:5])=[O:4])[NH2:1]

参加物

5

反応物 3

HCID 1049PyridineHCID 11200ChlorodimethylarsineHCID 124886Glutathione

生成物 1

HCID 11683005Darinaparsin

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

In a 500 mL flask, 7 g of glutathione was used as received from the Aldrich Chemical Co., purity 98% and dissolved in 250 mL of 1,2-dimethoxyethane. To this solution was added 3.3 g of dimethylchloroarsine. This was followed by the addition of 3.5 g of pyridine (redistilled after drying over NaOH pellets). The solution was refluxed for one hour after which time it was stirred at room temperature for three hours.

後処理

  1. temperatureThe solution was refluxed for one hour after which time it

出典と根拠

ORDレコード
ord-1d2d7a40ffad4f6f89dc233d9c543997
出典データセット
uspto-grants-2008_07
特許番号
US07405314B2

関連ノート

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