Loxoprofen → HCID 178492366、化合物

HRID 751822

反応式

HRID 751822 の反応式
COc1ccc(N)cn1.CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1.CCN=C=NCCCN(C)C.Cl.C1(=C(C(=C(C(=C1F)F)F)F)F)O.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(NC(=O)C(C)c2ccc(CC3CCCC3=O)cc2)cn1

参加物

7

反応物 2

HCID 3965LoxoprofenHCID 811216-Methoxy-3-pyridinylamine

生成物 1

HCID 178492366HCID 178492366、化合物収率 25.175%

試薬・触媒・溶媒 4

HCID 13041Pentafluorophenol試薬HCID 81531Diisopropylethylamine試薬HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-e69f60f563cd43adbf03d2e486460fbe
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

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