Acetyl chloride → HCID 178418832、化合物

HRID 7526

反応式

HRID 7526 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.[CH:10]1([N+:16]#[C-:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH:24]=O.[C:26](Cl)(=[O:28])[CH3:27]>Cl(O)(=O)(=O)=O>[Cl-:8].[C:26]([N+:1]1[C:24]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][N:18]=2)=[C:17]([NH:16][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[N:3]2[C:4]([NH2:9])=[CH:5][C:6]([Cl:8])=[N:7][C:2]=12)(=[O:28])[CH3:27]

参加物

6

反応物 4

HCID 6367Acetyl chlorideHCID 142732-PyridinecarboxaldehydeHCID 674322,4-Diamino-6-chloropyrimidineHCID 79129Cyclohexyl isocyanide

生成物 1

HCID 178418832HCID 178418832、化合物

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid溶媒

実験手順

Example 20 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) pyridine-2-carbaldehyde solution (0.3 M, DCM) and 10 μL perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

出典と根拠

ORDレコード
ord-a84129bb511c44ffb0e8e3eade59bb5b
出典データセット
uspto-grants-2006_08
特許番号
US07087607B2

関連ノート

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