Acetaldehyde → HCID 178419096、化合物

HRID 7531

反応式

HRID 7531 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.[CH:10]1([N+:16]#[C-:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.[CH:18](=[O:20])[CH3:19].[C:21]([Cl:24])(=O)[CH3:22]>Cl(O)(=O)(=O)=O>[Cl-:8].[C:18]([N+:7]1[C:6]([CH3:5])=[C:17]([NH:16][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[N:3]2[C:4]([NH2:9])=[CH:22][C:21]([Cl:24])=[N:1][C:2]=12)(=[O:20])[CH3:19]

参加物

6

反応物 4

HCID 177AcetaldehydeHCID 6367Acetyl chlorideHCID 674322,4-Diamino-6-chloropyrimidineHCID 79129Cyclohexyl isocyanide

生成物 1

HCID 178419096HCID 178419096、化合物

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid溶媒

実験手順

Example 25 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) acetaldehyde solution (0.3 M, DCM) and 10 μL perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

出典と根拠

ORDレコード
ord-d226efdb4de84acf86dab433a563b9d9
出典データセット
uspto-grants-2006_08
特許番号
US07087607B2

関連ノート

読み込み中…