2-Propanol, 1-amino-2-methyl- → Methyl 2-(4-chlorophenyl)-3-(2-hydroxy-2-methylpropylamino)propanoate
反応式
[NH2:1][CH2:2][C:3]([CH3:6])([OH:5])[CH3:4].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=[CH2:19])[C:15]([O:17][CH3:18])=[O:16])=[CH:10][CH:9]=1>O1CCCC1>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([CH:14]([CH2:19][NH:1][CH2:2][C:3]([OH:5])([CH3:6])[CH3:4])[C:15]([O:17][CH3:18])=[O:16])=[CH:12][CH:13]=1参加物
4
実験手順
1-Amino-2-methyl-propan-2-ol (0.408 g, 4.58 mmol) was added to a solution of methyl 2-(4-chlorophenyl)acrylate (0.300 g, 1.52 mmol) in tetrahydrofuran (3.84 mL). The reaction was allowed to stir at room temperature overnight and produced crude methyl 2-(4-chlorophenyl)-3-(2-hydroxy-2-methylpropylamino)propanoate (436 mg, 100%). LCMS: M+1 286.5.
出典と根拠
- ORDレコード
- ord-8540affbea47465aa01b8fb0617ffe81
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08835434B2
反応ノート
読み込み中…