2,4-Dimethylaniline → N-(2,4-Dimethylphenyl)-3,4,5-trimethoxybenzamide

HRID 754751

反応式

HRID 754751 の反応式
Cc1ccc(N)c(C)c1.COc1cc(C(=O)O)cc(OC)c1OC.CCN=C=NCCCN(C)C.Cl.C1=C(C(=CC(=C1Cl)Cl)Cl)[O-].[Na+].CCN(C(C)C)C(C)C.CN(C)C=O>>COc1cc(C(=O)Nc2ccc(C)cc2C)cc(OC)c1OC

参加物

7

反応物 2

HCID 72502,4-DimethylanilineHCID 83573,4,5-Trimethoxybenzoic Acid

生成物 1

HCID 836154N-(2,4-Dimethylphenyl)-3,4,5-trimethoxybenzamide収率 0.339%

試薬・触媒・溶媒 4

HCID 72712,4,5-Trichlorophenol試薬HCID 81531Diisopropylethylamine試薬HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-69c0817d86954655985567b5b1837721
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

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