Methanol → (S)-2-(2-(4-(3-(2,4-difluorophenyl)ureido)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid

HRID 75857ノート

反応式

HRID 75857 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:34])[NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[S:19][CH:20]=[C:21]([C:23]([NH:25][C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29]C)=[O:28])=[O:24])[N:22]=2)=[CH:14][CH:13]=1.CO.[Li+].[OH-]>C1COCC1>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:34])[NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[S:19][CH:20]=[C:21]([C:23]([NH:25][C@@H:26]([CH:31]([CH3:32])[CH3:33])[C:27]([OH:29])=[O:28])=[O:24])[N:22]=2)=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 887MethanolHCID 3939Lithium HydroxideHCID 67352417(S)-methyl 2-(2-(4-(3-(2,4-difluorophenyl)ureido)phenyl)thiazole-4-carboxamido)-3-methylbutanoate

生成物 1

HCID 67354364(S)-2-(2-(4-(3-(2,4-difluorophenyl)ureido)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of (S)-methyl 2-(2-(4-(3-(2,4-difluorophenyl)ureido)phenyl)thiazole-4-carboxamido)-3-methylbutanoate (100 mg, 0.204 mmol) in THF (4 mL)+MeOH (1 ml), 1 ml of 1N LiOH (42.99 mg, 1.024 mmol) was added at RT and stirred for 2-3 hr. After completion of reaction, THF was removed under reduced pressure. Obtained material was dissolved in water, acidified with 1N HCl and white solid precipitated out. It was filtered and dried.

後処理

  1. customwas removed under reduced pressure
  2. dissolutionObtained material was dissolved in water
  3. customprecipitated out
  4. filtrationIt was filtered
  5. customdried

出典と根拠

ORDレコード
ord-1fbf55b980f44011868a5e3060d4bc64
出典データセット
uspto-grants-2014_09
特許番号
US08835428B2

反応ノート

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