Chloroacetonitrile → 2-(4-Benzylpiperazin-1-yl)acetonitrile

HRID 7598

反応式

HRID 7598 の反応式
Cl[CH2:2][C:3]#[N:4].[CH2:5]([N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1COCC1.CCN(CC)CC>[CH2:5]([N:12]1[CH2:17][CH2:16][N:15]([CH2:2][C:3]#[N:4])[CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

参加物

5

反応物 2

HCID 7856ChloroacetonitrileHCID 759941-Benzylpiperazine

生成物 1

HCID 38557212-(4-Benzylpiperazin-1-yl)acetonitrile

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8471Triethylamine溶媒

実験手順

An excess of chloroacetonitrile (7 ml) was added in to a solution of benzylpiperazine (2 g, 10.5 mmol) in THF (100 ml) and Et3N (10 ml). The reaction was stirred for 10 hours before quenched with saturated aqueous NaHCO3 (100 ml). The aqueous phase was extracted with EtOAc (3×100 ml). The combined organic layer was dried over MgSO4 and concentrated to a residue, which was used in the further reactions without any purification.

後処理

  1. custombefore quenched with saturated aqueous NaHCO3 (100 ml)
  2. extractionThe aqueous phase was extracted with EtOAc (3×100 ml)
  3. dry with materialThe combined organic layer was dried over MgSO4
  4. concentrationconcentrated to a residue, which
  5. customwas used in the further reactions without any purification

出典と根拠

ORDレコード
ord-f3be17d383a14b1f9a00d9ceecf8569f
出典データセット
uspto-grants-2006_08
特許番号
US07087610B2

関連ノート

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