Chloroacetonitrile → 2-(4-Benzylpiperazin-1-yl)acetonitrile
反応式
Cl[CH2:2][C:3]#[N:4].[CH2:5]([N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1COCC1.CCN(CC)CC>[CH2:5]([N:12]1[CH2:17][CH2:16][N:15]([CH2:2][C:3]#[N:4])[CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1参加物
5
実験手順
An excess of chloroacetonitrile (7 ml) was added in to a solution of benzylpiperazine (2 g, 10.5 mmol) in THF (100 ml) and Et3N (10 ml). The reaction was stirred for 10 hours before quenched with saturated aqueous NaHCO3 (100 ml). The aqueous phase was extracted with EtOAc (3×100 ml). The combined organic layer was dried over MgSO4 and concentrated to a residue, which was used in the further reactions without any purification.
後処理
- custombefore quenched with saturated aqueous NaHCO3 (100 ml)
- extractionThe aqueous phase was extracted with EtOAc (3×100 ml)
- dry with materialThe combined organic layer was dried over MgSO4
- concentrationconcentrated to a residue, which
- customwas used in the further reactions without any purification
出典と根拠
- ORDレコード
- ord-f3be17d383a14b1f9a00d9ceecf8569f
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087610B2
反応ノート
読み込み中…