Diisopropyl Ether → D-tert-leucine

HRID 76842

反応式

HRID 76842 の反応式
C(OC(C)C)(C)C.[NH2:8][C@H:9]([C:14]([OH:16])=[O:15])[C:10]([CH3:13])([CH3:12])[CH3:11]>CC(C)=O>[NH2:8][C@@H:9]([C:14]([OH:16])=[O:15])[C:10]([CH3:13])([CH3:12])[CH3:11]

参加物

4

反応物 2

HCID 7914Diisopropyl EtherHCID 164608L-tert-Leucine

生成物 1

HCID 6950340D-tert-leucine収率 90%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

The filtrate obtained at dibenzoyl-d-tartrate salt stage (step.ii), was treated with a small amount of diisopropyl ether to remove any traces of dibenzoyl-d-tartaric acid and was concentrated under reduced pressure at 55° C. The residue obtained was stirred with small amount of acetone and filtered to obtain D-tert-leucine as a colorless solid (90% yield, 98.8% D-tert-leucine and 1.2% L-tert-leucine).

後処理

  1. customto remove any traces of dibenzoyl-d-tartaric acid
  2. concentrationwas concentrated under reduced pressure at 55° C
  3. customThe residue obtained
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-2717b3f8bfa84c05a7accb02e8c22307
出典データセット
uspto-grants-2014_09
特許番号
US08835676B2

関連ノート

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