1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 4-Cyclohexyl-N-((S)-6-{[(4-methoxybenzyl)(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide

HRID 77417ノート

反応式

HRID 77417 の反応式
[CH:1]1([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:16]([N:18]=C=NCCCN(C)C)C.ON1C2C=CC=CC=2N=N1.C(N(C(C)C)CC)(C)C.[CH3:46][O:47][C:48]1[CH:75]=[CH:74][C:51]([CH2:52][N:53]([CH2:61][C:62]2[CH:63]=[C:64]3[C:69](=[CH:70][CH:71]=2)[CH2:68][C@@H:67](CN)[CH2:66][CH2:65]3)[CH2:54][CH:55]2[CH2:60][CH2:59][O:58][CH2:57][CH2:56]2)=[CH:50][CH:49]=1>CN(C=O)C>[CH:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:11]([N:18]([C@H:67]3[CH2:66][CH2:65][C:64]4[C:69](=[CH:70][CH:71]=[C:62]([CH2:61][N:53]([CH2:52][C:51]5[CH:50]=[CH:49][C:48]([O:47][CH3:46])=[CH:75][CH:74]=5)[CH2:54][CH:55]5[CH2:60][CH2:59][O:58][CH2:57][CH2:56]5)[CH:63]=4)[CH2:68]3)[CH3:16])=[O:13])=[CH:14][CH:15]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

7

反応物 5

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 883374-Cyclohexylbenzoic acidHCID 66663221((S)-6-{[(4-methoxybenzyl)(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)methylamine

生成物 1

HCID 666634144-Cyclohexyl-N-((S)-6-{[(4-methoxybenzyl)(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 4-cyclohexylbenzoic acid (45 mg), DMF (1 ml), 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (hydrochloride, 45 mg) and 1-hydroxybenzotriazole (32 mg) was admixed after 5 minutes with diisopropylethylamine (30 mg) and ((S)-6-{[(4-methoxybenzyl)-(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)methylamine (80 mg). Volatile fractions were removed after 12 hours. The residue was purified by preparative HPLC. The product was thus obtained with the molecular weight of 594.84 (C28H38N2O3); MS (ESI) 595 (M+H+).

後処理

  1. customVolatile fractions were removed after 12 hours
  2. customThe residue was purified by preparative HPLC
  3. customThe product was thus obtained with the molecular weight of 594.84 (C28H38N2O3)

出典と根拠

ORDレコード
ord-74f7da7f13c648b3827561fbfc97f193
出典データセット
uspto-grants-2014_09
特許番号
US08841290B2

反応ノート

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