Ammonia → (4-(5-Methyl-furan-2-ylmethyl)-phenyl)-methanol

To a mixture of lithium aluminumhydride (230 mg, 4.9 mmol) and tetrahydrofuran (15 mL) was added aluminum chloride (830 mg, 6.2 mmol) at 0° C., which was stirred for 30 minutes at room temperature. A mixture of 4-(hydroxy-(5-methyl-furan-2-yl)-methyl)-benzaldehyde (320 mg, 1.5 mmol) described in Manufacturing Example 46-1-1 and tetrahydrofuran (5 mL) was added dropwise into the reaction mixture at 0° C., and stirred for 2 hours at that temperature. A 28% aqueous ammonia solution was added dropwise into the reaction mixture at the same temperature to quench the excess reagent. The reaction mixture was cooled to room temperature, and filtered by being passed through a Celite bed. The filtrate was concentrated under a reduced pressure to obtain the title compound (330 mg) as a crude product. This compound was used in the following reaction without further purification.

1. additionwas added dropwise into the reaction mixture at 0° C.
2. stirringstirred for 2 hours at that temperature
3. customto quench the excess reagent
4. temperatureThe reaction mixture was cooled to room temperature
5. filtrationfiltered
6. concentrationThe filtrate was concentrated under a reduced pressure

ORDレコード

ord-b0eb777ae6a74d7ea3169732f47b0d2e

出典データセット

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08841327B2