4-Quinolinecarboxylic acid → 4-Quinolinecarbonyl chloride
反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([OH:13])=O)=[CH:3][CH:2]=1.S(Cl)([Cl:16])=O>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([Cl:16])=[O:13])=[CH:3][CH:2]=1参加物
3
実験手順
A solution of 4-quinolinecarboxylic acid (Aldrich, 0.25 g, 1.4 mmol) in 5 mL of thionyl chloride was warmed to reflux and allowed to stir for 1 hour. The mixture was then cooled to ambient temperature and concentrated under reduced pressure. This material was dissolved in 10 mL toluene and concentrated under reduced pressure (3×) to afford the title compound.
後処理
- temperatureto reflux
- concentrationconcentrated under reduced pressure
- dissolutionThis material was dissolved in 10 mL toluene
- concentrationconcentrated under reduced pressure (3×)
出典と根拠
- ORDレコード
- ord-cdafd995a22746e6b7c3dd5a072b0f2f
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841334B2
反応ノート
読み込み中…