4-Quinolinecarboxylic acid → 4-Quinolinecarbonyl chloride

HRID 78439

反応式

HRID 78439 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([OH:13])=O)=[CH:3][CH:2]=1.S(Cl)([Cl:16])=O>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([Cl:16])=[O:13])=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 102434-Quinolinecarboxylic acidHCID 24386Thionyl Chloride

生成物 1

HCID 99901264-Quinolinecarbonyl chloride

実験手順

A solution of 4-quinolinecarboxylic acid (Aldrich, 0.25 g, 1.4 mmol) in 5 mL of thionyl chloride was warmed to reflux and allowed to stir for 1 hour. The mixture was then cooled to ambient temperature and concentrated under reduced pressure. This material was dissolved in 10 mL toluene and concentrated under reduced pressure (3×) to afford the title compound.

後処理

  1. temperatureto reflux
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThis material was dissolved in 10 mL toluene
  4. concentrationconcentrated under reduced pressure (3×)

出典と根拠

ORDレコード
ord-cdafd995a22746e6b7c3dd5a072b0f2f
出典データセット
uspto-grants-2014_09
特許番号
US08841334B2

関連ノート

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