N-bromobutanimide → Methyl 3-Amino-6-bromopyrazine-2-carboxylate

HRID 78555

反応式

HRID 78555 の反応式
[NH2:1][C:2]1[C:3]([C:8]([O:10][CH3:11])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.[Br:12]N1C(=O)CCC1=O>CC#N>[NH2:1][C:2]1[C:3]([C:8]([O:10][CH3:11])=[O:9])=[N:4][C:5]([Br:12])=[CH:6][N:7]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 72669Methyl 3-aminopyrazinecarboxylate

生成物 1

HCID 227251Methyl 3-Amino-6-bromopyrazine-2-carboxylate収率 92.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of methyl 3-aminopyrazine-2-carboxylate (8.35 g, 54.53 mmol) and N-bromo-succinimide (9.705 g, 54.53 mmol) was stirred in MeCN (100 mL) at room temp overnight. The resultant precipitate was filtered, washed with MeCN and dried to give the desired product as a yellow solid (11.68 g, 92% Yield)

後処理

  1. filtrationThe resultant precipitate was filtered
  2. washwashed with MeCN
  3. customdried

出典と根拠

ORDレコード
ord-9c45557af7b8499583d6e81ed74ae82b
出典データセット
uspto-grants-2014_09
特許番号
US08841308B2

関連ノート

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