N-bromobutanimide → Methyl 3-Amino-6-bromopyrazine-2-carboxylate
反応式
[NH2:1][C:2]1[C:3]([C:8]([O:10][CH3:11])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.[Br:12]N1C(=O)CCC1=O>CC#N>[NH2:1][C:2]1[C:3]([C:8]([O:10][CH3:11])=[O:9])=[N:4][C:5]([Br:12])=[CH:6][N:7]=1参加物
4
実験手順
A mixture of methyl 3-aminopyrazine-2-carboxylate (8.35 g, 54.53 mmol) and N-bromo-succinimide (9.705 g, 54.53 mmol) was stirred in MeCN (100 mL) at room temp overnight. The resultant precipitate was filtered, washed with MeCN and dried to give the desired product as a yellow solid (11.68 g, 92% Yield); 1H NMR (400.0 MHz, DMSO) 3.85 (s, 3H), 7.55 (br s, 2H) and 8.42 (s, 1H) ppm; MS (ES+) 233
後処理
- filtrationThe resultant precipitate was filtered
- washwashed with MeCN
- customdried
出典と根拠
- ORDレコード
- ord-95349889551e442692e50934cd213786
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841308B2
反応ノート
読み込み中…