Acetic Acid → 9a-butyl-8-chloro-6-fluoro-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one

A solution of crude 2-butyl-4-chloro-6-fluoro-5-methoxy-1-indanone (386 mg, 1.4 mmol) in tetrahydrofuran (2.8 mL) was treated with methyl vinyl ketone (0.150 mL, 1.78 mmol) and 0.5N sodium methoxide in methanol (1.1 mL, 0.56 mmol). The mixture was stirred at room temperature for 5.5 hours to effect conversion to 2-butyl-4-chloro-6-fluoro-5-methoxy-2-(3-oxobutyl)-1-indanone. The reaction mixture was diluted with toluene (10 mL), treated with pyrrolidine (0.117 mL, 1.4 mmol) and acetic acid (0.112 mmol, 1.46 mmol), and then stirred and heated in an oil bath at 80° C. for 3 hours. After storing overnight at room temperature, the mixture was partitioned between EtOAc (50 mL) and water (50 mL). The organic phase was washed with 0.1N HCl (50 mL), saturated aqueous NaHCO3 (50 mL) and brine (20 mL), dried over MgSO4, filtered, and evaporated under vacuum. The oily residue was purified by preparative layer chromatography on four 0.1×20×20 cm silica gel GF plates, developing with 5% EtOAc in CH2Cl2. The product bands were combined, eluted with EtOAc, and the eluent evaporated under vacuum to provide 9a-butyl-8-chloro-6-fluoro-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one (160 mg) as a solid. 1H NMR spectroscopy revealed that the product contained a minor amount of the isomeric product 9a-butyl-6-chloro-8-fluoro-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one which is derived from a minor amount of 2-butyl-6-chloro-4-fluoro-5-methoxy-1-indanone in the starting material.

1. stirringstirred
2. temperatureheated in an oil bath at 80° C. for 3 hours
3. waitAfter storing overnight at room temperature
4. customthe mixture was partitioned between EtOAc (50 mL) and water (50 mL)
5. washThe organic phase was washed with 0.1N HCl (50 mL), saturated aqueous NaHCO3 (50 mL) and brine (20 mL)
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customevaporated under vacuum
9. customThe oily residue was purified by preparative layer chromatography on four 0.1×20×20 cm silica gel GF plates
10. washeluted with EtOAc
11. customthe eluent evaporated under vacuum

ORDレコード

ord-f4004a05731743db9d750d86b5473e91

出典データセット

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07087599B2