Benzenesulfonamide, 3-amino- → N-(3-sulfamoylphenyl)-4-(trifluoromethoxy)benzamide

HRID 79094

反応式

HRID 79094 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([S:8]([NH2:11])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[F:12][C:13]([F:25])([F:24])[O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1>N1C=CC=CC=1>[NH2:11][S:8]([C:4]1[CH:3]=[C:2]([NH:1][C:19](=[O:20])[C:18]2[CH:22]=[CH:23][C:15]([O:14][C:13]([F:12])([F:24])[F:25])=[CH:16][CH:17]=2)[CH:7]=[CH:6][CH:5]=1)(=[O:9])=[O:10]

参加物

4

反応物 2

HCID 7377Benzenesulfonamide, 3-amino-HCID 1421104-(Trifluoromethoxy)benzoyl Chloride

生成物 1

HCID 4784511N-(3-sulfamoylphenyl)-4-(trifluoromethoxy)benzamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 3-amino-benzenesulfonamide (17 mg, 0.10 mmol) in pyridine (1 mL) was added 4-trifluoromethoxy benzoyl chloride (16 μL, 0.10 mmol). The reaction was stirred at room temperature for 15 h and purified by preparative reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) to give N-(3-(aminosulfonyl)phenyl)-4-(trifluoromethoxy)benzamide. LC/MS: m/z 360.9 (M+H)+ at 3.02 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).

後処理

  1. custompurified by preparative reverse phase

出典と根拠

ORDレコード
ord-0ad32f6959f3494a890a8ff7c4c23a47
出典データセット
uspto-grants-2014_09
特許番号
US08841483B2

関連ノート

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