Methanol → Urea, 1-(2-chloroethyl)-3-(2-naphthyl)-

HRID 80103

反応式

HRID 80103 の反応式
[Cl:1][CH2:2][CH2:3][N:4]=[C:5]=[O:6].[CH:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][C:8]=1[NH2:17].CO>C1(C)C=CC=CC=1.C(Cl)(Cl)Cl>[Cl:1][CH2:2][CH2:3][NH:4][C:5]([NH:17][C:8]1[CH:9]=[CH:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1)=[O:6]

参加物

6

反応物 3

HCID 887MethanolHCID 70572-NaphthylamineHCID 160352-Chloroethyl isocyanate

生成物 1

HCID 256650Urea, 1-(2-chloroethyl)-3-(2-naphthyl)-収率 83.2%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 6212Chloroform溶媒

実験手順

1-Chloro-2-isocyanato-ethane (0.81 mL, 9.42 mmol) was added dropwise to a stirred solution of naphthalen-2-ylamine (900 mg, 6.28 mmol) in toluene (50 mL) over a period of 30 minutes at 0° C. The reaction temperature was maintained at room temperature for 5 hours. The reaction was monitored by TLC (5% MeOH in chloroform). The reaction mixture was filtered, washed with toluene and dried under reduced pressure to afford 1.3 g (83% yield) of 1-(2-chloro-ethyl)-3-naphthalen-2-yl-urea.

後処理

  1. filtrationThe reaction mixture was filtered
  2. washwashed with toluene
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-7d1e7ba22c45424894f9727198bc3033
出典データセット
uspto-grants-2014_09
特許番号
USRE045173E1

関連ノート

読み込み中…