Methyl iodide → HCID 68784434、化合物
反応式
[Br:1][C:2]1[C:10]2[C:9]([C:11]#[N:12])=[CH:8][CH:7]=[CH:6][C:5]=2[NH:4][CH:3]=1.[H-].[Na+].CI.[CH2:17](OC(=O)C)C>CN(C=O)C.CCCCCC>[Br:1][C:2]1[C:10]2[C:9]([C:11]#[N:12])=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]([CH3:17])[CH:3]=1参加物
7
反応条件
- 温度
- 0 °C
実験手順
3-Bromo-1H-indole-4-carbonitrile (I-146a: 500 mg, 2.272 mmol) was added dropwise to a stirred mixture of NaH (0.218 g, 9.0833 mmol) in dry DMF (15 mL) at 0° C. over a period of 10 minutes. This was followed by the addition of methyl iodide and the resulting mixture was stirred at 0° C. for 2 hours. The reaction was monitored by TLC (10% ethylacetate in hexane). The reaction mixture was quenched with ice water; the precipitate formed was collected and dried to afford 0.400 g of the crude product.
後処理
- customThe reaction mixture was quenched with ice water
- customthe precipitate formed
- customwas collected
- customdried
出典と根拠
- ORDレコード
- ord-fe7571c1bd6646c4b46fa82476120ef4
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- USRE045173E1
反応ノート
読み込み中…