Water → 2-((Triphenylmethyl)amino)ethanol

HRID 80299

反応式

HRID 80299 の反応式
[C:1]1([C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)Cl)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:21][CH:22](O)[CH3:23].[OH2:25]>C(#N)C>[C:1]1([C:7]([NH:21][CH2:22][CH2:23][OH:25])([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 962WaterHCID 6456Trityl chlorideHCID 522583Acetaldehyde ammonia

生成物 1

HCID 31256082-((Triphenylmethyl)amino)ethanol収率 39%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Triphenylchloromethane (1.00 g, 3.58 mmol) (Wako Pure Chemical Industries, Ltd.) and aminoethanol (2.00 g, 32.7 mmol) were dissolved in acetonitrile (5 mL), and the solution was stirred at room temperature overnight. Water (100 mL) was poured into the reaction solution, and the precipitates were suction-filtered and then dried. The solid product was recrystallized from a mixed solvent of ethanol (Wako Pure Chemical Industries, Ltd.) and water, to thereby obtain the title compound (0.43 g, 39% yield).

後処理

  1. filtrationthe precipitates were suction-filtered
  2. customdried
  3. customThe solid product was recrystallized from a mixed solvent of ethanol (Wako Pure Chemical Industries, Ltd.) and water

出典と根拠

ORDレコード
ord-c8024df5c705406a8ff8676a83e574f1
出典データセット
uspto-grants-2014_09
特許番号
US08846012B2

関連ノート

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