Sodium Hydroxide → 4-(6-(4-Isopropylpiperazin-1-yl)-pyridin-3-yl)-benzylamine

反応式

[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH:7]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[N:21]=[CH:20][C:19]([C:22]3[CH:29]=[CH:28][C:25]([C:26]#[N:27])=[CH:24][CH:23]=3)=[CH:18][CH:17]=2)[CH2:12][CH2:11]1)([CH3:9])[CH3:8].[OH-].[Na+]>C1COCC1>[CH:7]([N:10]1[CH2:11][CH2:12][N:13]([C:16]2[N:21]=[CH:20][C:19]([C:22]3[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=3)=[CH:18][CH:17]=2)[CH2:14][CH2:15]1)([CH3:9])[CH3:8]

参加物

実験手順

A mixture of a 1 M solution of LiAlH4 in THF (1.1 mL, 1.1 mmol) and dry THF (10 mL) was placed under an atmosphere of nitrogen. A solution of 4-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)benzonitrile (306 mg, 1.0 mmol, prepared as described in Example 10) in dry THF (5 mL) was added dropwise. The reaction mixture was then stirred at rt for 3 h and quenced with 1 N NaOH. The mixture was filtered and the volatiles were removed. The residue was re-evaporated with THF to give 310 mg (100%) of 4-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl]benzylamine.