ホーム MCP ワークベンチ Skills

ホームワークベンチ通知マイページ

llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

ホーム
反応

Water → rel-Phenylmethyl (3R,4R)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methoxy-1-piperidinecarboxylate

HRID 81349

印刷プレビュー

反応式

HRID 81349 の反応式

[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])[CH2:11][C@@H:10]1[OH:25])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].[CH3:28]OS(OC)(=O)=O.O>C1COCC1.[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1>[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])[CH2:11][C@H:10]1[O:25][CH3:28])=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 6497Dimethyl Sulfate

HCID 14798Sodium Hydroxide

HCID 58303445Phenylmethyl (3S,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-1-piperidinecarboxylate

生成物 1

HCID 58522570rel-Phenylmethyl (3R,4R)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methoxy-1-piperidinecarboxylate

試薬・触媒・溶媒 2

HCID 66133

Benzyl triethylammonium chloride

触媒

HCID 8028Tetrahydrofuran溶媒

実験手順

benzyl (3S,4S)-4-tert-butoxycarbonylamino-3-hydroxy-piperidine-1-carboxylate (5.00 g) is dissolved in THF (6 mL) and combined with 30 mL aqueous, semiconcentrated NaOH solution, benzyltriethylammonium chloride as well as dimethylsulphate (2.26 mL). After 22 h H2O (200 mL) is added and the mixture is extracted with EtOAc (150 mL). The organic phase is dried on magnesium sulphate, filtered off from the desiccant and the solvent is eliminated in vacuo. Purification is carried out using a silica gel column (cHex/EtOAc 65/35).

後処理

extractionthe mixture is extracted with EtOAc (150 mL)
customThe organic phase is dried on magnesium sulphate
filtrationfiltered off from the desiccant and the solvent
customPurification

出典と根拠

ORDレコード: ord-4ced7a16961f4e099f0f5614f0aa8edc
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08846689B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート