m-Bromobenzenesulphonyl chloride → 1-(3-Bromobenzenesulfonyl)-4-methylpiperazine

HRID 81482

反応式

HRID 81482 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][C:9]1[CH:10]=[C:11]([S:15](Cl)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1>N1C=CC=CC=1.Cl>[Br:8][C:9]1[CH:10]=[C:11]([S:15]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1

参加物

5

反応物 2

HCID 17943m-Bromobenzenesulphonyl chlorideHCID 531671-Methylpiperazine

生成物 1

HCID 294021141-(3-Bromobenzenesulfonyl)-4-methylpiperazine

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 1049Pyridine溶媒

実験手順

A solution of 1-methylpiperazine (0.072 ml, 0.65 mmol) and 3-bromobenzene-1-sulfonyl chloride (0.2 g, 0.78 mmol) in pyridine (3 ml) is stirred at room temperature for 2 hours. The reaction mixture is diluted with 2M HCl, and extracted with DCM. The aqueous layer is made basic with 2M NaOH, and is extracted with DCM. The DCM layers are combined, dried (MgSO4) and the solvent removed in vacuo to afford the title compound as an orange oil. [M+H]+ 345.

後処理

  1. extractionextracted with DCM
  2. extractionis extracted with DCM
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-c748f04c3b984371bea84924a0a5c617
出典データセット
uspto-grants-2014_09
特許番号
US08846687B2

関連ノート

読み込み中…