Hydrochloric Acid → Sodium Chloride

HRID 81618ノート

反応式

HRID 81618 の反応式
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8](OC)=[CH:7][N:6]=1)=[O:4].[OH-:14].[Na+:15].[ClH:16].[C:17]1(C)C=CC=CC=1>C1COCC1>[NH2:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][C:7]([O:14][CH3:17])=[CH:8][N:9]=1.[Cl-:16].[Na+:15]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 14798Sodium HydroxideHCID 53438909Methyl 3-amino-5-methoxypyrazine-2-carboxylate

生成物 2

HCID 5234Sodium ChlorideHCID 167380163-Amino-6-methoxypyrazine-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 200 mg (1.092 mmol) 3-amino-5-methoxy-pyrazine-2-carboxylic acid methyl ester in 4 ml THF was added 1.20 ml (1.20 mmol) i N sodium hydroxide and the mixture was stirred at room temperature for 29 h. To the mixture were added 1.09 ml (1.09 mmol) 1N HCl after stirring for 5 min toluene was added and the solvents were evaporated to provide the title compound together with sodium chloride as colorless solid. The mixture was used for coupling reactions without further purification.

後処理

  1. additionwas added
  2. customthe solvents were evaporated

出典と根拠

ORDレコード
ord-ae70d9e4fbc240f39dbb9fefd5283c58
出典データセット
uspto-grants-2014_09
特許番号
US08846658B2

反応ノート

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