Water → Ethyl 2-(2-bromo-5-fluoroisonicotinoyl)-3-(dimethylamino)acrylate

反応式

[Br:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[OH:7])[c:8]([F:11])[cH:9][n:10]1.[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:16][N:17]([CH:18]=[CH:19][C:20](=[O:21])[O:22][CH2:23][CH3:24])[CH3:25].[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[CH3:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1.[OH2:45].[S:12]([Cl:13])([Cl:14])=[O:15]>>[Br:1][c:2]1[cH:3][c:4]([C:5](=[O:7])[C:19](=[CH:18][N:17]([CH3:16])[CH3:25])[C:20](=[O:21])[O:22][CH2:23][CH3:24])[c:8]([F:11])[cH:9][n:10]1