Lithium Hydroxide → HCID 67326429、化合物

HRID 82477

反応式

HRID 82477 の反応式
C[O:2][C:3](=[O:17])[C:4]([NH2:16])([C:8]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:9])[CH:5]([CH3:7])[CH3:6].C1COCC1.[Li+].[OH-]>CO.O>[CH3:6][CH:5]([CH3:7])[C:4]([NH2:16])([C:8]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:9])[C:3]([OH:17])=[O:2]

参加物

6

反応物 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 673255273-Methyl-2-[pyridine-3-carbonyl]-amino-butyric acid methyl ester

生成物 1

HCID 67326429HCID 67326429、化合物収率 99%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
25 °C

実験手順

To a solution of 3-methyl-2-[pyridine-3-carbonyl]-amino-butyric acid methyl ester (1.5 g, 6.3 mmol), in methanol (15 mL), THF (9 mL) was added LiOH (1.3 g, 31.7 mmol) dissolved in water (3 mL). The mixture was allowed to stir at room temperature (25° C.) over 2 h. Solvent was evaporated from reaction mixture, dissolved in water (15 mL), acidified with 1.5N HCl extracted with ethyl acetate (150 mL), dried over sodium sulphate and concentrated to obtain product as yellow colour solid (1.38 g, 99%).

後処理

  1. customSolvent was evaporated from reaction mixture
  2. dissolutiondissolved in water (15 mL)
  3. extractionextracted with ethyl acetate (150 mL)
  4. dry with materialdried over sodium sulphate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-15fe4b8c7f4a47eca4088ce693a8f5da
出典データセット
uspto-grants-2014_09
特許番号
US08846721B2

関連ノート

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