Methyl iodide → HCID 58577771、化合物

HRID 82612ノート

反応式

HRID 82612 の反応式
[H-].[Na+].[CH3:3][S:4]([C:7]1[NH:11][C:10]2[CH2:12][CH2:13][CH2:14][CH2:15][C:9]=2[N:8]=1)(=[O:6])=[O:5].[CH3:16]I.[Cl-].[Cl-].[Ca+2]>CO>[CH3:16][N:11]1[C:10]2[CH2:12][CH2:13][CH2:14][CH2:15][C:9]=2[N:8]=[C:7]1[S:4]([CH3:3])(=[O:5])=[O:6]

参加物

6

反応物 4

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 5284359Calcium ChlorideHCID 585774122-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-benzimidazole

生成物 1

HCID 58577771HCID 58577771、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium hydride (55.8 mg) (60% in mineral oil) was added to a solution of 2-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-benzimidazole (233 mg) and MeI (0.080 mL) in DMF(dry) (10 ml) at room temperature. The mixture was stirred at room temperature under a dry atmosphere (CaCl2 tube) for 1 h. The reaction mixture was diluted with MeOH (2 mL), and concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with 0%-30% EtOAc in hexane) to give 1-methyl-2-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-benzimidazole (200 mg) as a white solid.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by column chromatography (silica gel, eluted with 0%-30% EtOAc in hexane)

出典と根拠

ORDレコード
ord-a5f8c702c40d4153bdb053ad85556559
出典データセット
uspto-grants-2014_09
特許番号
US08846713B2

反応ノート

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