Water → 3-(6-Amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-ylmethyl)phenyl-2-thiophenesulphonamide

HRID 8295

反応式

HRID 8295 の反応式
N[C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[CH2:5][N:6]1[C:10]2=[N:11][C:12]([NH2:20])=[N:13][C:14]([C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)=[C:9]2[CH:8]=[N:7]1.[S:24]1[CH:28]=[CH:27][CH:26]=[C:25]1[S:29](Cl)(=[O:31])=[O:30].O.[N:34]1C=CC=CC=1>>[NH2:20][C:12]1[N:11]=[C:10]2[N:6]([CH2:5][C:4]3[CH:3]=[C:2]([C:26]4[CH:27]=[CH:28][S:24][C:25]=4[S:29]([NH2:34])(=[O:31])=[O:30])[CH:23]=[CH:22][CH:21]=3)[N:7]=[CH:8][C:9]2=[C:14]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[N:13]=1

参加物

5

反応物 4

HCID 962WaterHCID 1049PyridineHCID 855182-Thiophenesulfonyl chlorideHCID 220154991-(3-Aminobenzyl)-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine

生成物 1

HCID 866051273-(6-Amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-ylmethyl)phenyl-2-thiophenesulphonamide収率 22%

実験手順

A solution of 1-(3-aminobenzyl)-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine (153 mg, 0.5 mmol) in pyridine (2 mL) was treated with 2-thiophenesulphonyl chloride (91 mg, 0.5 mmol), stirred at room temperature for 16 h, poured into water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo and purified by chromatography (MeOH:DCM, 1:99) to give the title compound (49 mg, 22%) as a cream solid.

後処理

  1. extractionextracted with EtOAc
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated in vacuo
  4. custompurified by chromatography (MeOH:DCM, 1:99)

出典と根拠

ORDレコード
ord-df00543d4c174ad98bde971596d1cfc6
出典データセット
uspto-grants-2006_08
特許番号
US07087754B2

関連ノート

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