Trifluoroacetic acid → HCID 86680360、化合物

HRID 83519ノート

反応式

HRID 83519 の反応式
C([O:5][C:6]([C@H:8]1[CH2:12][NH:11][C:10](=[O:13])[N:9]1[CH3:14])=[O:7])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[CH3:14][N:9]1[C@@H:8]([C:6]([OH:7])=[O:5])[CH2:12][NH:11][C:10]1=[O:13]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86680358(R)-3-Methyl-2-oxoimidazolidine-4-carboxylic Acid tert-butyl Ester

生成物 1

HCID 86680360HCID 86680360、化合物収率 76.9%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a solution of (R)-3-methyl-2-oxoimidazolidine-4-carboxylic acid tert-butyl ester (94 mg) in chloroform (2 ml) was added trifluoroacetic acid (1 ml) at room temperature, and the mixture was stirred for 3 hours. This reaction solution was concentrated under reduced pressure, additional toluene (3 ml) was added thereto, and the mixture was again concentrated. To the resulting residue was added diethyl ether (0.5 ml) at room temperature, and the mixture was stirred. Next, n-hexane (2 ml) was added thereto, and the mixture was further stirred. The insoluble substance was collected by filtration, and dried under reduced pressure to give the titled compound (52 mg).

後処理

  1. concentrationThis reaction solution was concentrated under reduced pressure, additional toluene (3 ml)
  2. additionwas added
  3. concentrationthe mixture was again concentrated
  4. additionTo the resulting residue was added diethyl ether (0.5 ml) at room temperature
  5. stirringthe mixture was stirred
  6. additionNext, n-hexane (2 ml) was added
  7. filtrationThe insoluble substance was collected by filtration
  8. customdried under reduced pressure

出典と根拠

ORDレコード
ord-bca779d571af4ab59a57660b8c9f29b6
出典データセット
uspto-grants-2014_09
特許番号
US08846746B2

反応ノート

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