Water → Methyl 1-(4-chlorobenzyl)-1H-pyrrole-2-carboxylate

HRID 83592

反応式

HRID 83592 の反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([O:8][CH3:9])=[O:7].C([O-])([O-])=O.[K+].[K+].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23]Cl)=[CH:19][CH:18]=1.O>CN(C=O)C>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][N:1]2[CH:5]=[CH:4][CH:3]=[C:2]2[C:6]([O:8][CH3:9])=[O:7])=[CH:19][CH:18]=1

参加物

6

反応物 4

HCID 962WaterHCID 77231-Chloro-4-(chloromethyl)benzeneHCID 11430Potassium CarbonateHCID 136930Methyl pyrrole-2-carboxylate

生成物 1

HCID 50900833Methyl 1-(4-chlorobenzyl)-1H-pyrrole-2-carboxylate収率 86.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

Methyl 1H-pyrrole-2-carboxylate (330 mg, 2.64 mmol) was dissolved in anhydrous DMF (8 mL). Solid K2CO3 (547 mg, 3.96 mmol) was added, followed by the addition of 1-chloro-4-(chloromethyl)benzene (638 mg, 3.96 mmol). The reaction was permitted to stir at 60° C. for 36 h, at which time the reaction was allowed to cool to rt. Water was added and the resulting precipitate was isolated over a filter, and dried under high vacuum overnight to give 570 mg of the title compound.

後処理

  1. temperatureto cool to rt
  2. customthe resulting precipitate was isolated over a filter
  3. customdried under high vacuum overnight

出典と根拠

ORDレコード
ord-d73f26653a394f2297a022d50ebf2dea
出典データセット
uspto-grants-2014_09
特許番号
US08846684B2

関連ノート

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