Chloromethyl Methyl Ether → Methyl alpha-amino-alpha-(4-methoxymethoxyphenyl)acetate

HRID 839449

反応式

HRID 839449 の反応式
[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[H-].[Na+].[H][H].[CH3:18][O:19][CH2:20]Cl>O.CN(C)C=O>[NH2:1][CH:2]([C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:18][O:19][CH3:20])=[CH:11][CH:12]=1)[C:3]([O:5][CH3:6])=[O:4]

参加物

7

反応物 4

HCID 7864Chloromethyl Methyl EtherHCID 24758Sodium hydrideHCID 4123006p-Hydroxyphenylglycine methyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 20324417Methyl alpha-amino-alpha-(4-methoxymethoxyphenyl)acetate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

In this preparation 1.81 g. of methyl α-amino-α-(4-hydroxyphenyl)acetate is dissolved in 10 ml. of dimethylformamide under nitrogen and 0.24 g. of sodium hydride is then added. The solution is stirred at room temperature under nitrogen until hydrogen evolution ceases and then 0.80 g. of chloromethyl methyl ether is added. The resulting mixture is warmed at 60° C for 1 hour and then cooled and diluted with water. The aqueous mixture is extracted with ether and the ether extract is dried and evaporated to afford methyl α-amino-α-(4-methoxymethoxyphenyl)acetate.

後処理

  1. customIn this preparation 1.81 g
  2. temperaturecooled
  3. extractionThe aqueous mixture is extracted with ether
  4. extractionthe ether extract
  5. customis dried
  6. customevaporated

出典と根拠

ORDレコード
ord-b59e5b18ad26420caf07f211fcad7334
出典データセット
uspto-grants-1978_06
特許番号
US04094978

関連ノート

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