Acetanilide → 4'-Chloroacetyl(acetanilide)

HRID 840167

反応式

HRID 840167 の反応式
[Cl:1][CH2:2][C:3](Cl)=[O:4].[C:6]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:8])[CH3:7].[Cl-].[Al+3].[Cl-].[Cl-]>ClCCCl>[Cl:1][CH2:2][C:3]([C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:6](=[O:8])[CH3:7])=[CH:11][CH:12]=1)=[O:4]

参加物

5

反応物 3

HCID 904AcetanilideHCID 6577Chloroacetyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 88054'-Chloroacetyl(acetanilide)

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

反応条件

温度
60 °C

実験手順

23.5 mmol of chloroacetyl chloride and, in portions, 18.1 mmol of acetanilide, are added slowly, under an argon atmosphere, to 108 mmol of aluminium chloride in 90 ml of 1,2-dichloroethane. The reaction mixture is heated at 60° C. for 2 hours and then cooled with an ice bath. After slow hydrolysis using ice, and filtration, the precipitate obtained is washed with ethyl ether and dried. The expected product so obtained is used in the following without being purified.

後処理

  1. temperaturecooled with an ice bath
  2. customAfter slow hydrolysis
  3. filtrationice, and filtration
  4. customthe precipitate obtained
  5. washis washed with ethyl ether
  6. customdried

出典と根拠

ORDレコード
ord-8302ee1b619a44479dd5e646e1a4a518
出典データセット
uspto-grants-2002_04
特許番号
US06365605B1

関連ノート

読み込み中…